A INFLUÊNCIA DA VITAMINA D NA DOENÇA PERIODONTAL
Palavras-chave:
VITAMINA D, DOENÇA PERIODONTAL, CALCITRIOL, PERIODONTO, PERIODONTITE
Resumo
A Vitamina D, ou calcitrol (forma ativa) é um hormônio esteroide que tem como principal função a regulação da homeostase do fósforo, cálcio e também atua na formação e reabsorção óssea. Conhecida popularmente como vitamina D, pode se apresentar de duas formas, sendo D2 (ergocalciferol), cujas fontes são bem restritas e D3 (colicalciferol) forma ativa, que tem como molécula de origem o colesterol, sintetizados na pele através dos raios UVB e também advindos de algumas fontes naturais. Cerca de 30 a 50% da população apresentam níveis baixos de vitamina D no organismo, tal deficiência se observa não somente em pacientes com baixos níveis de densidade óssea, mas também em pacientes com doenças crônicas e inflamatórias, como é o caso da doença periodontal; que agride o periodonto, sendo este, a estrutura de suporte do elemento dentário. Este artigo é uma revisão de literatura que tem como objetivo a análise do papel da vitamina D na homeostase do cálcio no organismo e suas propriedades anti-inflamatórias correlacionadas com a patogênese da doença periodontal.
Referências
1. DeLuca H. History of the discovery of vitamin D and its active metabolites. BoneKEy Reports. 2014; 3; Article number: 479.
2. McCollum EV, Davis M. The necessity of certain lipins in the diet during growth. J Biol Chem. 1913; 25: 167-175.
3. Holick MF. Vitamina D como um tratamento tão simples pode reverter doenças tão importantes. Fundamento; 2012.
4. Phillips KM, Horst RL, Koszewski NJ, Simon RR. Vitamin D4 in mushrooms. PLoS ONE. 2012; 7.
5. Keegan RJ, Lu Z, Bogusz JM, Williams JE, Holick MF. Photobiology of vitamin D in mushrooms and its bioavailability in humans. Dermatoendocrinology. 2013; 5: 165–176.
6. Urbain P, Valverde J, Jakobsen J. Impact on vitamin D2, vitamin D4 and agaritine in Agaricus bisporus mushrooms after artificial and natural solar UV light exposure. Plant Food Hum. Nutr. 2016; 71: 314–321.
7. Taofiq O, Fernandes A, Barros L, Barreiro MF, Ferreira ICFR. UV-irradiated mushrooms as a source of vitamin D2: A review. Trends Food Sci. Technol. 2017; 70: 82–94.
8. Bikle DD. Vitamin D metabolism, mechanism of action, and clinical applications. Chem Biol. 2014; 21(3): 319-29.
9. Nithya A, Chandrasekaran SC, Narpat SR. Vitamin D and periodontal health: Current concepts. J Indian Soc Periodontol. 2013; 17(3): 302-308.
10. Kuula H, Salo T, Pirila E, Tuomainen AM, Jauhiainen M, Uitto V, et al. Local and systemic responses in matrix metalloproteinase 8-deficient mice during Porphyromonas gingivalis-induced periodontitis. Infect Immun. 2009; 77(2): 850-859.
11. Ng SK, Leung WK. A community study on the relationship between stress, coping, affective dispositions and periodontal attachment loss. Community Dent Oral Epidemiol. 2006; 34: 252-66.
12. Nazir MA. Prevalence of periodontal disease, its association with systemic diseases and prevention. Int J Health Sci (Qassim). 2017;11(2): 72-80.
13. Konig J, Holtfreter B, Kocher T. Periodontal health in Europe: future trends based on treatment needs and the provision of periodontal services--position paper 1. Eur J Dent Educ. 2010; 14(Suppl 1): 4-24
14. Ministério da saúde. Pesquisa Nacional de Saúde Bucal. [Publicação na web]; 2012 acesso em 30 de janeiro de 2020. Disponível em: http://bvsms.saude.gov.br/bvs/publicacoes/pesquisa_nacional_saude_bucal.pdf
15. Gutner M, Chaushu S, Balter D, Bachrach G. Saliva enables the antimicrobial activity of LL-37 in the presence of proteases of Porphyromonas gingivalis. Infect Immun. 2009; 77: 5558-5563.
16. Garcia M, Hildebolt C, Miley D, et al. One-year Effects of Vitamin D and Calcium Supplementation on Chronic Periodontitis. J Periodontol. 2011; 82: 25-32.
17. White JH. Vitamin D Signaling, Infectious Diseases and Regulation of Innate Immunity. Infect Immun. 2008; 76: 3837-3843.
18. Cochran DL. Inflammation and Bone Loss in Periodontal Disease. J Periodontol. 2008; 79(Suppl.8): 1569-1576.
19. Martineau AR, Wilkinson KA, Newton SM et al. IFN gamma and TNF-independent vitamin D-inducible human suppression of mycobacteria: the role of cathelicidin LL-37. J Immunol. 2007; 178: 7190-7198.
20. Newman MG, Takei H, Klokkevold PR, Carranza F. Carranza’s clinical periodontology. 12a ed. Elsevier health sciences; 2011.
21. Eley BM, Soory M, Manson JD. Periodontia. 6a ed. Saunders-Elsevier. 2012
22. Holmstrup P, Plemons J, Meyle J. Non–plaque‐induced gingival diseases. J Periodontol. 2018; 89(S); S28–S43.
23. Murakami S, Mealey BL, Mariotti A, Chapple ILC. Dental plaque‐in‐ duced gingival conditions. J Periodontol. 2018; 89(Suppl 1): S17-S27.
24. Ramseier CA, Ånerud, Dulac M, et al. Natural history of peri‐ odontitis: disease progression and tooth loss over 40 years. J Clin Periodontol. 2017; 44: 1182-1191.
25. Yucel-Lindberg T, Båge T. Inflammatory mediators in the pathogenesis of periodontitis. Expert Rev Mol Med. 2013;15(7).
26. Khammissa RA, Feller L, Meyerov R, Lemmer J. Peri-implant mucositis and peri-implantitis: bacterial infection. SADJ. 2012; 67(2): 70-74.
27. Tang X, Pan Y, Zhao Y. Vitamin D inhibits the expression of interleukin-8 in human periodontal ligament cells stimulated with Porphyromonas gingivalis. Archives of Oral Biology. 2013; 58(4): 397-407.
28. Di Benedetto A, Gigante I, Colucci S, Grano M. Periodontal disease: linking the primary inflammation to bone loss. Clin Dev Immunol. 2013; 2013: 1-7.
29. Lane J. Investigation into toll like receptor mechanisms of action, in relation to Porphyromonas gingivalis in periodontitis. The Plymouth Student Scientist. 2013; 6(2): 355-367.
30. Zhang W, Swearingen EB, Ju J, Rigney T, Tribble GD. Porphyromonas gingivalis invades osteoblasts and inhibits bone formation. Microbes and Infection. 2010; 12(11): 838-845.
31. Zhang P, Wu Y, Jiang Z, Jiang L, Fang B. Osteogenic response of mesenchymal stem cells to continuous mechanical strain is dependent on ERK1/2-Runx2 signaling. Int J of Molecular Medicine. 2012; 29(6): 1083-1089.
32. Kassab P, Colombier M, Kaminski M, Lelong N, Sixou M, Nabet C. Impact of periodontitis definition in epidemiological research. Results from the EPIPAP study in postpartum women. Eur J Oral Sci. 2011; 119: 156-162.
33. Bastos J, Ferreira de Andrade L, Ferreira P, Barroso E, Daibert P, Barreto P, et al. Níveis séricos de vitamina D e periodontite crônica em pacientes com doença renal crônica. Jornal Brasileiro de Nefrologia. 2013; 35(1): 20-26.
34. Kucharz EJ. The forgotten discovery of the oral infection role in the development of systemic disorders. Eur J Intern Med. 2011; 22(3).
35. Grant WB, Boucher BJ. Are Hill’s criteria for causality satisfied for vitamin D and periodontal disease?. Dermato-Endocrinology. 2010; 2(1): 30-36.
36. Schulze-Spate U, Turner R, Wang Y, Chao R, Schulze P, Phipps K, et al. Relationship of bone metabolism biomarkers and periodontal disease: the osteoporotic fractures in men (MrOS) study. Journal of Clinical Endocrinology & Metabolism. 2015; 100(6): 2425-2433.
37. Kassebaum NJ, Bernabe E, Dahiya M, Bhandari B, Murray CJ, Marcenes W. Global burden of severe periodontitis in 1990–2010: a systematic review and meta-regression. J Dent Res. 2014; 93(11):1045–53.
38. Machado V, Botelho J, Albernaz J, Proença L, Alves R, Cavacas M, et al. The Prevalence of Periodontal Diseases in Portugal and Correspondent Digital National Awareness: Analysis of Data from Global Burden of Disease, Directorate-General of Health and Google Trends for the Period 2004-2017. Rev Portuguesa de estomatologia e cirurgia maxilo-facial. 2020. 61:
39. Bostanci N, Belibasakis G. Periodontal Pathogenesis: Definitions and Historical Perspectives. Pathogenesis of Periodontal Diseases. 2018: 6-12.
40. Hospital Círio Libanês [página na internet]. Hospital Círio Libanês - A importância da vitamina D [acesso em 15 de março de 2020]. Disponível em: https://www.hospitalsiriolibanes.org.br/imprensa/noticias/Paginas/A-import%C3%A2ncia-da-vitamina-D.aspx
41. Vásquez-Awad D, Guzmán R. Osteoporosis: enfoque clínico y tratamiento. 1a Ed. Bogotá: Kimpres; 2012.
42. Vásquez-Awad D. Vitamina D y su importancia en la Salud Humana. Medicina. 2013; 35 (3): 214-226.
43. Holick M, Binkley N, Bischoff-Ferrari H, Gordon C, Hanley D, Heaney R, et al. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. Journal of Clinical Endocrinology & Metabolism. 2011; 96(7): 1911-1930.
44. Zuluaga N, Alfaro J, González V, Jiménez K, Campuzano G. Vitamina D: Nuevos Paradigmas. Medicina y laboratório. 2011; 17(5): 211-246.
45. Pike J, Meyer M, Benkusky N, Lee S, John H, Carlson A, et al. Genomic Determinants of Vitamin D-Regulated Gene Expression. Vitam Horm. 2016; 100: 21-44.
46. Castro L, O sistema endocrinológico vitamina D. Arq Bras Endocrinol Metab. 2011; 55(8)
47. Cashman K. Vitamin D: dietary requirements and food fortification as a means of helping achieve adequate vitamin D status. Journal of Steroid Biochemistry and Molecular Biology. 2015; 148: 19-26.
48. Rosen CJ, Adams JS, Bikle DD, Black DM, Demay MB, Manson JE, et al. The nonskeletal effects of vitamin D: an Endocrine Society scientific statement. Endocr Ver. 2012; 33: 456-92.
49. Cianferotti L, Cricelli C, Kanis JA, Nuti R, Reginster JY, Rizzoli R, et al. The clinical use of vitamin D metabolites and their potential developments: a position statement from the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO) and the International Osteoporosis Foundation (IOF). Endocrine. 2015; 50 (1): 12- 26.
50. Rosero O. Vitamina D y Salud ósea en la mujer postmenopáusica. Revisión. Revista ACE. 2015; 2 (1): 14-9.
51. Palacios C, Gonzalez L. Is vitamin D deficiency a major global public health problem? J Steroid Biochem Mol Biol. 2014; 144: 138-45.
52. Hilger J, Friedel A, Herr R, Rausch T, Roos F, Wahl DA, et al. A systematic review of vitamin D status in populations worldwide. Br J Nutr. 2013; 9: 1-23.
53. Martineau A, Cates C, Urashima M, Jensen M, Griffiths A, Nurmatov U, et al. Vitamin D for the management of asthma. Cochrane Database of Systematic Reviews. 2016; 9 (9).
54. Sgardi F, Carmo E, Rosa L. Radiação ultravioleta e carcinogênese. Revista de Ciencias Medicas. 2012; 16(4): 245-250.
55. Melo M, Ribeiro C. Novas Considerações sobre a Fotoproteção no Brasil: Revisão de Literatura. Revista Ciências em Saúde. 2015; 5 (3).
56. Gontijo L, Bustamante P, Souza R. A fotoproteção como ferramenta de saúde pública no Brasil. Revista Eletrônica Parlatorium. 2016; 4: 4-12.
57. Muir S, Montero-Odasso M. Effect of vitamin D supplementation on muscle strength, gait and balance in older adults: a systematic review and meta-analysis. Journal of the American Geriatrics Society. 2011. 59 (12): 2291-2300.
58. Rosen C, Adams J, Bikle D, Black D, Demay M, Manson J, et al. The nonskeletal effects of vitamin D: an Endocrine Society scientific statement. Endocrine Reviews. 2012; 33 (3): 456-492.
59. Amano Y, Komiyama K, Makishima M. Vitamin D and periodontal disease. Journal of Oral Science. 2009; 51 (1): 11-20.
60. Zhan Y, Samietz S, Holtfreter B, Hannemann A, Meisel P, Nauck M, et al. Prospective study of serum 25-hydroxy vitamin D and tooth loss. Journal of Dental Research. 2014; 93 (7): 639-644.
61. Antonucci R, Locci C, Clemente MG, Chicconi E, Antonucci L. Vitamin D deficiency in childhood: Old lessons and current challenges. J. Pediatr. Endocrinol. Metab. 2018; 31: 247-260.
62. D’Amelio P, Cristofaro MA, De Vivo E, Ravazzoli M, Grosso E, Di Bella S, et al. Platelet vitamin D receptor is reduced in osteoporotic patients. Panminerva Med. 2012; 54: 225-231.
63. Bischoff-Ferrari HA, Willett WC, Orav EJ, Lips P, Meunier PJ, Lyons RA, et al. A pooled analysis of vitamin D dose requirements for fracture prevention. N Engl J Med. 2012; 367(1):40-9.
64. Linden GJ, Lyons A, Scannapieco FA. Periodontal systemic associations: Review of the evidence. J Clin Periodontol. 2013; 40: S8-S19.
65. Holick MF. Vitamin D status: measurement, interpretation, and clinical application. Ann Epidemiol. 2009;19(2):73-8.
66. Holick MF, Vitamin D update 2015: what we need to know about its health benefits and potential for toxicity?. Standardy Medyczne Pediatria. 2012; 12 (5): 759-765.
67. Miley D, Garcia M, Hildebolt C, Shannon W, Couture R, Spearie C, et al. Cross-sectional study of vitamin D and calcium supplementation effects on chronic periodontitis. Journal of Periodontology. 2009; 80 (9): 1433-1439.
68. Garcia M, Hidebolt C, Miley D, Dixon D, Couture R, Spearie C, et al. One-year effects of vitamin D and calcium supplementation on chronic periodontitis. Journal of Periodontology. 2011; 82 (1): 25-32.
69. Alshouibi E, Kaye E, Cabral H, Leone C, Garcia R. Vitamin D and periodontal health in older men. Journal of Dental Research. 2013; 92 (8): 689-693.
70. Millen AE, Hovey KM, LaMonte MJ, Swanson M, Andrews CA, Kluczynski MA, et al. Plasma 25-hydroxyvitamin D concentrations and periodontal disease in postmenopausal women. J Periodontol. 2013; 84(9):1243-56.
71. Alshouibi EN, Kaye EK, Cabral HJ, Leone CW, Garcia RI. Vitamin D and periodontal health in older men. J Dent Res. 2013; 92(8): 689-93.
72. Millen AE, Andrews CA, Lamonte MJ, Hovey KM, Swanson M, Genco RJ, et al. Vitamin D status and 5-year changes in periodontal disease measures among postmenopausal women: the Buffalo OsteoPerio Study. J Periodontol. 2014; 85(10):1321-32.
73. Christakos S, Dhawan P, Verstuyf A, Verlinden L, Carmeliet G. Vitamin D: metabolism, molecular mechanism of action, and pleiotropic effects. Physiological Reviews. 2016; 96 (1): 365-408.
74. Boggess K, Espinola J, Moss K, BeckJ, Offenbacher S, Camargo C. Vitamin D status and periodontal disease among pregnant women. Journal of Periodontology. 2011; 82 (2): 195-200.
75. Dietrich T, Garcia R. Associations between periodontal disease and systemic disease: evaluating the strength of the evidence. Journal of Periodontology. 2005; 76 (11): 2175-2184.
76. Millen A, Hovey K, Lamonte M, Swanson M, Andrews C, Kluczynski M, et al. Plasma 25-hydroxyvitamin D concentrations and periodontal disease in postmenopausal women. Journal of Periodontology. 2013; 84 (9): 1243-1256.
77. Bashutski J, Eber R, Kinney J, Benavides E, Maitra S, Brauin T, et al. The impact of vitamin D status on periodontal surgery outcomes. Journal of Dental Research. 2011; 90 (8): 1007-1012.
78. Gurav AN. Periodontitis and insulin resistance: Casual or causal relationship?. Diabetes Metab J. 2012; 36: 404-11.
79. Lim SG, Han K, Kim HA, Pyo SW, Cho YS, Kim KS, et al. Association between insulin resistance and periodontitis in Korean adults. J Clin Periodontol. 2014; 41: 121-30.
80. Sun WL, Chen LL, Zhang SZ, Wu YM, Ren YZ, Qin GM. Inflammatory cytokines, adiponectin, insulin resistance and metabolic control after periodontal intervention in patients with Type 2 diabetes and chronic periodontitis. Intern Med. 2011; 50: 1569-74.
81. Mezza T, Muscogiuri G, Sorice GP, Prioletta A, Salomone E, Pontecorvi A, et al. Vitamin D deficiency: a new risk factor for type 2 diabetes?. Ann. Nutr. Metab. 2012; 61: 337-348.
82. Pilz S, Kienreich K, Rutters F, de Jongh R, van Ballegooijen AJ, Grübler M, et al. Role of vitamin D in the development of insulin resistance and type 2 diabetes. Curr. Diab. Rep. 2013; 13: 261-270.
83. Tandon V, Tangade P, Lingesha R, Tirth A, Pal S, Yadav V. Glycemic Control and Periodontal Disease in Type 2 Diabetes Mellitus Patients: A Cross-Sectional Study. Journal of Indian Association of Public Health Dentistry. 2015; 13 (3): 297-301.
2. McCollum EV, Davis M. The necessity of certain lipins in the diet during growth. J Biol Chem. 1913; 25: 167-175.
3. Holick MF. Vitamina D como um tratamento tão simples pode reverter doenças tão importantes. Fundamento; 2012.
4. Phillips KM, Horst RL, Koszewski NJ, Simon RR. Vitamin D4 in mushrooms. PLoS ONE. 2012; 7.
5. Keegan RJ, Lu Z, Bogusz JM, Williams JE, Holick MF. Photobiology of vitamin D in mushrooms and its bioavailability in humans. Dermatoendocrinology. 2013; 5: 165–176.
6. Urbain P, Valverde J, Jakobsen J. Impact on vitamin D2, vitamin D4 and agaritine in Agaricus bisporus mushrooms after artificial and natural solar UV light exposure. Plant Food Hum. Nutr. 2016; 71: 314–321.
7. Taofiq O, Fernandes A, Barros L, Barreiro MF, Ferreira ICFR. UV-irradiated mushrooms as a source of vitamin D2: A review. Trends Food Sci. Technol. 2017; 70: 82–94.
8. Bikle DD. Vitamin D metabolism, mechanism of action, and clinical applications. Chem Biol. 2014; 21(3): 319-29.
9. Nithya A, Chandrasekaran SC, Narpat SR. Vitamin D and periodontal health: Current concepts. J Indian Soc Periodontol. 2013; 17(3): 302-308.
10. Kuula H, Salo T, Pirila E, Tuomainen AM, Jauhiainen M, Uitto V, et al. Local and systemic responses in matrix metalloproteinase 8-deficient mice during Porphyromonas gingivalis-induced periodontitis. Infect Immun. 2009; 77(2): 850-859.
11. Ng SK, Leung WK. A community study on the relationship between stress, coping, affective dispositions and periodontal attachment loss. Community Dent Oral Epidemiol. 2006; 34: 252-66.
12. Nazir MA. Prevalence of periodontal disease, its association with systemic diseases and prevention. Int J Health Sci (Qassim). 2017;11(2): 72-80.
13. Konig J, Holtfreter B, Kocher T. Periodontal health in Europe: future trends based on treatment needs and the provision of periodontal services--position paper 1. Eur J Dent Educ. 2010; 14(Suppl 1): 4-24
14. Ministério da saúde. Pesquisa Nacional de Saúde Bucal. [Publicação na web]; 2012 acesso em 30 de janeiro de 2020. Disponível em: http://bvsms.saude.gov.br/bvs/publicacoes/pesquisa_nacional_saude_bucal.pdf
15. Gutner M, Chaushu S, Balter D, Bachrach G. Saliva enables the antimicrobial activity of LL-37 in the presence of proteases of Porphyromonas gingivalis. Infect Immun. 2009; 77: 5558-5563.
16. Garcia M, Hildebolt C, Miley D, et al. One-year Effects of Vitamin D and Calcium Supplementation on Chronic Periodontitis. J Periodontol. 2011; 82: 25-32.
17. White JH. Vitamin D Signaling, Infectious Diseases and Regulation of Innate Immunity. Infect Immun. 2008; 76: 3837-3843.
18. Cochran DL. Inflammation and Bone Loss in Periodontal Disease. J Periodontol. 2008; 79(Suppl.8): 1569-1576.
19. Martineau AR, Wilkinson KA, Newton SM et al. IFN gamma and TNF-independent vitamin D-inducible human suppression of mycobacteria: the role of cathelicidin LL-37. J Immunol. 2007; 178: 7190-7198.
20. Newman MG, Takei H, Klokkevold PR, Carranza F. Carranza’s clinical periodontology. 12a ed. Elsevier health sciences; 2011.
21. Eley BM, Soory M, Manson JD. Periodontia. 6a ed. Saunders-Elsevier. 2012
22. Holmstrup P, Plemons J, Meyle J. Non–plaque‐induced gingival diseases. J Periodontol. 2018; 89(S); S28–S43.
23. Murakami S, Mealey BL, Mariotti A, Chapple ILC. Dental plaque‐in‐ duced gingival conditions. J Periodontol. 2018; 89(Suppl 1): S17-S27.
24. Ramseier CA, Ånerud, Dulac M, et al. Natural history of peri‐ odontitis: disease progression and tooth loss over 40 years. J Clin Periodontol. 2017; 44: 1182-1191.
25. Yucel-Lindberg T, Båge T. Inflammatory mediators in the pathogenesis of periodontitis. Expert Rev Mol Med. 2013;15(7).
26. Khammissa RA, Feller L, Meyerov R, Lemmer J. Peri-implant mucositis and peri-implantitis: bacterial infection. SADJ. 2012; 67(2): 70-74.
27. Tang X, Pan Y, Zhao Y. Vitamin D inhibits the expression of interleukin-8 in human periodontal ligament cells stimulated with Porphyromonas gingivalis. Archives of Oral Biology. 2013; 58(4): 397-407.
28. Di Benedetto A, Gigante I, Colucci S, Grano M. Periodontal disease: linking the primary inflammation to bone loss. Clin Dev Immunol. 2013; 2013: 1-7.
29. Lane J. Investigation into toll like receptor mechanisms of action, in relation to Porphyromonas gingivalis in periodontitis. The Plymouth Student Scientist. 2013; 6(2): 355-367.
30. Zhang W, Swearingen EB, Ju J, Rigney T, Tribble GD. Porphyromonas gingivalis invades osteoblasts and inhibits bone formation. Microbes and Infection. 2010; 12(11): 838-845.
31. Zhang P, Wu Y, Jiang Z, Jiang L, Fang B. Osteogenic response of mesenchymal stem cells to continuous mechanical strain is dependent on ERK1/2-Runx2 signaling. Int J of Molecular Medicine. 2012; 29(6): 1083-1089.
32. Kassab P, Colombier M, Kaminski M, Lelong N, Sixou M, Nabet C. Impact of periodontitis definition in epidemiological research. Results from the EPIPAP study in postpartum women. Eur J Oral Sci. 2011; 119: 156-162.
33. Bastos J, Ferreira de Andrade L, Ferreira P, Barroso E, Daibert P, Barreto P, et al. Níveis séricos de vitamina D e periodontite crônica em pacientes com doença renal crônica. Jornal Brasileiro de Nefrologia. 2013; 35(1): 20-26.
34. Kucharz EJ. The forgotten discovery of the oral infection role in the development of systemic disorders. Eur J Intern Med. 2011; 22(3).
35. Grant WB, Boucher BJ. Are Hill’s criteria for causality satisfied for vitamin D and periodontal disease?. Dermato-Endocrinology. 2010; 2(1): 30-36.
36. Schulze-Spate U, Turner R, Wang Y, Chao R, Schulze P, Phipps K, et al. Relationship of bone metabolism biomarkers and periodontal disease: the osteoporotic fractures in men (MrOS) study. Journal of Clinical Endocrinology & Metabolism. 2015; 100(6): 2425-2433.
37. Kassebaum NJ, Bernabe E, Dahiya M, Bhandari B, Murray CJ, Marcenes W. Global burden of severe periodontitis in 1990–2010: a systematic review and meta-regression. J Dent Res. 2014; 93(11):1045–53.
38. Machado V, Botelho J, Albernaz J, Proença L, Alves R, Cavacas M, et al. The Prevalence of Periodontal Diseases in Portugal and Correspondent Digital National Awareness: Analysis of Data from Global Burden of Disease, Directorate-General of Health and Google Trends for the Period 2004-2017. Rev Portuguesa de estomatologia e cirurgia maxilo-facial. 2020. 61:
39. Bostanci N, Belibasakis G. Periodontal Pathogenesis: Definitions and Historical Perspectives. Pathogenesis of Periodontal Diseases. 2018: 6-12.
40. Hospital Círio Libanês [página na internet]. Hospital Círio Libanês - A importância da vitamina D [acesso em 15 de março de 2020]. Disponível em: https://www.hospitalsiriolibanes.org.br/imprensa/noticias/Paginas/A-import%C3%A2ncia-da-vitamina-D.aspx
41. Vásquez-Awad D, Guzmán R. Osteoporosis: enfoque clínico y tratamiento. 1a Ed. Bogotá: Kimpres; 2012.
42. Vásquez-Awad D. Vitamina D y su importancia en la Salud Humana. Medicina. 2013; 35 (3): 214-226.
43. Holick M, Binkley N, Bischoff-Ferrari H, Gordon C, Hanley D, Heaney R, et al. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. Journal of Clinical Endocrinology & Metabolism. 2011; 96(7): 1911-1930.
44. Zuluaga N, Alfaro J, González V, Jiménez K, Campuzano G. Vitamina D: Nuevos Paradigmas. Medicina y laboratório. 2011; 17(5): 211-246.
45. Pike J, Meyer M, Benkusky N, Lee S, John H, Carlson A, et al. Genomic Determinants of Vitamin D-Regulated Gene Expression. Vitam Horm. 2016; 100: 21-44.
46. Castro L, O sistema endocrinológico vitamina D. Arq Bras Endocrinol Metab. 2011; 55(8)
47. Cashman K. Vitamin D: dietary requirements and food fortification as a means of helping achieve adequate vitamin D status. Journal of Steroid Biochemistry and Molecular Biology. 2015; 148: 19-26.
48. Rosen CJ, Adams JS, Bikle DD, Black DM, Demay MB, Manson JE, et al. The nonskeletal effects of vitamin D: an Endocrine Society scientific statement. Endocr Ver. 2012; 33: 456-92.
49. Cianferotti L, Cricelli C, Kanis JA, Nuti R, Reginster JY, Rizzoli R, et al. The clinical use of vitamin D metabolites and their potential developments: a position statement from the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO) and the International Osteoporosis Foundation (IOF). Endocrine. 2015; 50 (1): 12- 26.
50. Rosero O. Vitamina D y Salud ósea en la mujer postmenopáusica. Revisión. Revista ACE. 2015; 2 (1): 14-9.
51. Palacios C, Gonzalez L. Is vitamin D deficiency a major global public health problem? J Steroid Biochem Mol Biol. 2014; 144: 138-45.
52. Hilger J, Friedel A, Herr R, Rausch T, Roos F, Wahl DA, et al. A systematic review of vitamin D status in populations worldwide. Br J Nutr. 2013; 9: 1-23.
53. Martineau A, Cates C, Urashima M, Jensen M, Griffiths A, Nurmatov U, et al. Vitamin D for the management of asthma. Cochrane Database of Systematic Reviews. 2016; 9 (9).
54. Sgardi F, Carmo E, Rosa L. Radiação ultravioleta e carcinogênese. Revista de Ciencias Medicas. 2012; 16(4): 245-250.
55. Melo M, Ribeiro C. Novas Considerações sobre a Fotoproteção no Brasil: Revisão de Literatura. Revista Ciências em Saúde. 2015; 5 (3).
56. Gontijo L, Bustamante P, Souza R. A fotoproteção como ferramenta de saúde pública no Brasil. Revista Eletrônica Parlatorium. 2016; 4: 4-12.
57. Muir S, Montero-Odasso M. Effect of vitamin D supplementation on muscle strength, gait and balance in older adults: a systematic review and meta-analysis. Journal of the American Geriatrics Society. 2011. 59 (12): 2291-2300.
58. Rosen C, Adams J, Bikle D, Black D, Demay M, Manson J, et al. The nonskeletal effects of vitamin D: an Endocrine Society scientific statement. Endocrine Reviews. 2012; 33 (3): 456-492.
59. Amano Y, Komiyama K, Makishima M. Vitamin D and periodontal disease. Journal of Oral Science. 2009; 51 (1): 11-20.
60. Zhan Y, Samietz S, Holtfreter B, Hannemann A, Meisel P, Nauck M, et al. Prospective study of serum 25-hydroxy vitamin D and tooth loss. Journal of Dental Research. 2014; 93 (7): 639-644.
61. Antonucci R, Locci C, Clemente MG, Chicconi E, Antonucci L. Vitamin D deficiency in childhood: Old lessons and current challenges. J. Pediatr. Endocrinol. Metab. 2018; 31: 247-260.
62. D’Amelio P, Cristofaro MA, De Vivo E, Ravazzoli M, Grosso E, Di Bella S, et al. Platelet vitamin D receptor is reduced in osteoporotic patients. Panminerva Med. 2012; 54: 225-231.
63. Bischoff-Ferrari HA, Willett WC, Orav EJ, Lips P, Meunier PJ, Lyons RA, et al. A pooled analysis of vitamin D dose requirements for fracture prevention. N Engl J Med. 2012; 367(1):40-9.
64. Linden GJ, Lyons A, Scannapieco FA. Periodontal systemic associations: Review of the evidence. J Clin Periodontol. 2013; 40: S8-S19.
65. Holick MF. Vitamin D status: measurement, interpretation, and clinical application. Ann Epidemiol. 2009;19(2):73-8.
66. Holick MF, Vitamin D update 2015: what we need to know about its health benefits and potential for toxicity?. Standardy Medyczne Pediatria. 2012; 12 (5): 759-765.
67. Miley D, Garcia M, Hildebolt C, Shannon W, Couture R, Spearie C, et al. Cross-sectional study of vitamin D and calcium supplementation effects on chronic periodontitis. Journal of Periodontology. 2009; 80 (9): 1433-1439.
68. Garcia M, Hidebolt C, Miley D, Dixon D, Couture R, Spearie C, et al. One-year effects of vitamin D and calcium supplementation on chronic periodontitis. Journal of Periodontology. 2011; 82 (1): 25-32.
69. Alshouibi E, Kaye E, Cabral H, Leone C, Garcia R. Vitamin D and periodontal health in older men. Journal of Dental Research. 2013; 92 (8): 689-693.
70. Millen AE, Hovey KM, LaMonte MJ, Swanson M, Andrews CA, Kluczynski MA, et al. Plasma 25-hydroxyvitamin D concentrations and periodontal disease in postmenopausal women. J Periodontol. 2013; 84(9):1243-56.
71. Alshouibi EN, Kaye EK, Cabral HJ, Leone CW, Garcia RI. Vitamin D and periodontal health in older men. J Dent Res. 2013; 92(8): 689-93.
72. Millen AE, Andrews CA, Lamonte MJ, Hovey KM, Swanson M, Genco RJ, et al. Vitamin D status and 5-year changes in periodontal disease measures among postmenopausal women: the Buffalo OsteoPerio Study. J Periodontol. 2014; 85(10):1321-32.
73. Christakos S, Dhawan P, Verstuyf A, Verlinden L, Carmeliet G. Vitamin D: metabolism, molecular mechanism of action, and pleiotropic effects. Physiological Reviews. 2016; 96 (1): 365-408.
74. Boggess K, Espinola J, Moss K, BeckJ, Offenbacher S, Camargo C. Vitamin D status and periodontal disease among pregnant women. Journal of Periodontology. 2011; 82 (2): 195-200.
75. Dietrich T, Garcia R. Associations between periodontal disease and systemic disease: evaluating the strength of the evidence. Journal of Periodontology. 2005; 76 (11): 2175-2184.
76. Millen A, Hovey K, Lamonte M, Swanson M, Andrews C, Kluczynski M, et al. Plasma 25-hydroxyvitamin D concentrations and periodontal disease in postmenopausal women. Journal of Periodontology. 2013; 84 (9): 1243-1256.
77. Bashutski J, Eber R, Kinney J, Benavides E, Maitra S, Brauin T, et al. The impact of vitamin D status on periodontal surgery outcomes. Journal of Dental Research. 2011; 90 (8): 1007-1012.
78. Gurav AN. Periodontitis and insulin resistance: Casual or causal relationship?. Diabetes Metab J. 2012; 36: 404-11.
79. Lim SG, Han K, Kim HA, Pyo SW, Cho YS, Kim KS, et al. Association between insulin resistance and periodontitis in Korean adults. J Clin Periodontol. 2014; 41: 121-30.
80. Sun WL, Chen LL, Zhang SZ, Wu YM, Ren YZ, Qin GM. Inflammatory cytokines, adiponectin, insulin resistance and metabolic control after periodontal intervention in patients with Type 2 diabetes and chronic periodontitis. Intern Med. 2011; 50: 1569-74.
81. Mezza T, Muscogiuri G, Sorice GP, Prioletta A, Salomone E, Pontecorvi A, et al. Vitamin D deficiency: a new risk factor for type 2 diabetes?. Ann. Nutr. Metab. 2012; 61: 337-348.
82. Pilz S, Kienreich K, Rutters F, de Jongh R, van Ballegooijen AJ, Grübler M, et al. Role of vitamin D in the development of insulin resistance and type 2 diabetes. Curr. Diab. Rep. 2013; 13: 261-270.
83. Tandon V, Tangade P, Lingesha R, Tirth A, Pal S, Yadav V. Glycemic Control and Periodontal Disease in Type 2 Diabetes Mellitus Patients: A Cross-Sectional Study. Journal of Indian Association of Public Health Dentistry. 2015; 13 (3): 297-301.
Publicado
2020-08-30
Como Citar
PELAEZ ARENAS, D., BARROS DE ASSIS DANTAS, L., & DE MORAES SCHELLER, A. (2020). A INFLUÊNCIA DA VITAMINA D NA DOENÇA PERIODONTAL. Revista Cathedral, 2(3), 49-63. Recuperado de http://cathedral.ojs.galoa.com.br/index.php/cathedral/article/view/178
Seção
Artigos
Os direitos autorais deste artigo serão licenciados para a Revista Cathedral da Faculdade Cathedral de Boa Vista-RR efetivamente se/e quando o artigo for aceito para publicação. O(s) autor(es) garante(m) que sua contribuição é original e que tem todo o poder para executar essa licença. Essa licença abrange o direito exclusivo da Revista Cathedral para reproduzir, publicar e distribuir o artigo, nacional e internacionalmente, incluindo reimpressões, traduções, reproduções fotográficas, microformas, formulários eletrônicos (offline, on-line) ou qualquer outra reprodução de natureza similar. Além disso, o(s) autor(es) compreendem que o manuscrito não pode ser reenviado para qualquer outro Jornal/Revista após ser publicado. Após aprovado, o(s) autor(es) pode(m) auto-arquivar uma
versão de seu artigo em seu próprio site e/ou em seu repositório institucional.
